AbstractFour cases of cicatricial ectropion secondary to prolonged systemic administration of 5‐fluorouracil are described. In 1 patient ectropion resolved with conservative treatment and discontinuation of 5‐FU. Another patient developed the ectropion terminally and died before its resolution. In 2 patients surgical repair of the ectropion was unsuccessful in relieving conjunctival symptoms while 5‐FU was continued. With prolonged adjuvant chemotherapy programs utilizing 5‐FU, this complication may be seen with increasing frequency. Conservative management should be attempted, and patients with this problem should be reassured that symptoms will resolve when 5‐FU i