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A Stability Indicating High Performance Liquid Chromatographic Assay of Isradipine in Pharmaceutical Preparations

 

作者: MahaF. A. Elghany,   BadrE. Elzeany,   MohammedA. Elkawy,   JamesT. Stewart,  

 

期刊: Analytical Letters  (Taylor Available online 1996)
卷期: Volume 29, issue 7  

页码: 1157-1165

 

ISSN:0003-2719

 

年代: 1996

 

DOI:10.1080/00032719608001465

 

出版商: Taylor & Francis Group

 

关键词: Isradipine;HPLC;Pharmaceuticals;Spectrometry.

 

数据来源: Taylor

 

摘要:

A high performance liquid chromatographic procedure has been developed for the assay of isradipine in bulk form and tablet and capsule pharmaceutical preparations. The separation is achieved within 20 min on an octadecylsilane column at ambient temperature with a mobile phase of 60:40 v/v methanol - water, a flow rate of 1 mL/min, and detection at 325 nm. Degradation studies showed no peak interference between isradipine and degradation products. It was also determined that the excipients in the commercial tablet and capsule preparations did not interfere with the assay. The method was linear in the range 10–60 μg/mL with accuracy and precision in the 0.40 - 1.53% range.

 

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