The effects of denervation on the localization of ▵5-3β-hydroxysteroid dehydrogenase activity in the rat ovary during pregnancy
作者:
Hubert W. Burden,
I. Irvin,
E. Lawrence, jr,
期刊:
Cells Tissues Organs
(Karger Available online 1977)
卷期:
Volume 97,
issue 3
页码: 286-290
ISSN:1422-6405
年代: 1977
DOI:10.1159/000144744
出版商: S. Karger AG
关键词: &karsi028;5-3β-hydroxysteroid dehydrogenase;Pregnenolone;Progesterone;Interstitial gland;Corpus luteum;Pregnancy;Rat;Denervation
数据来源: Karger
摘要:
The effect of denervation on △5-3β-hydroxysteroid dehydrogenase (3β-HSD) activity with pregnenolone as substrate was studied during pregnancy. The enzyme activity, that is interpreted as the capacity to secrete progesterone, was studied in both control and experimental pregnant rats. The ovaries of experimental rats were denervated 96 h prior to sacrifice. Denervation during early pregnancy did not affect 3β-HSD activity in the interstitial gland (IG) and corpus luteum (CL). However, denervation resulted in decreased activity in both the IG and CL on days 10, 14 and 18. This reduced activity is interpreted as a decreased capacity of denervated ovaries to synthesize progesterone at this time in pregn
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