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Treatment of 70+‐Year‐Olds With Recurrent Major DepressionExcellent Short‐Term But Brittle Long‐Term Response

 

作者: Charles Reynolds,   Ellen Frank,   Mary Dew,   Patricia Houck,   Mark Miller,   Sati Mazumdar,   James Perel,   David Kupfer,  

 

期刊: American Journal of Geriatric Psychiatry  (OVID Available online 1999)
卷期: Volume 7, issue 1  

页码: 64-69

 

ISSN:1064-7481

 

年代: 1999

 

出版商: OVID

 

关键词: Depression;Short-Term Therapy;Longitudinal Outcome

 

数据来源: OVID

 

摘要:

The authors compared response rates, by age (60–69 vs. 70+), to acute, continuation, and 1-year maintenance depression treatment. Patients (N=180) received open combined treatment with nortriptyline (NT)/placebo and interpersonal psychotherapy (IPT). Patients who recovered then entered randomized, double-blind maintenance treatment with NT or placebo or received maintenance monthly IPT (combined with NT or placebo). Comparison of time-to-remission and recovery and absolute rates of remission, relapse, recovery, and recurrence yielded similar times to/rates of remission and recovery; however, older patients had far more recurrence during the first year of maintenance therapy. Although responses to acute and continuation treatment with combined NT and psychotherapy were similar, the older group had more recurrence in the first year of maintenance. Continuation of combined medication and psychotherapy may represent the best long-term treatment.

 

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