Immunotherapy in Chronic Brucellosis. Effect of Levamisole and Interferon; Mechanisms of Action and Clinical Value
作者:
PrintzisS.,
RaptopoulouMaria,
OrphanoukoumerkeridouHelen,
LagreF.,
GoulisG,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1994)
卷期:
Volume 16,
issue 4
页码: 679-693
ISSN:0892-3973
年代: 1994
DOI:10.3109/08923979409019745
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractThirty two anergic patients with chronic brucellosis treated with a)interferon-alpha2b(group 1), b)levamisole (group 2) and c)conventional therapy(group 3) were studied. the effect of treatment on T lymphocyte blast formation in the presence of PHA, specific cell mediated immunity against brucella antigens, titers of brucella antibodies and clinical symptoms were evaluated T lymphocyte blast formation was shown to range in normal levels in all patients before treatment compared to 10 normal controls suggesting against a generalized impairment of cell mediated immunity. Titers of brucella antibodies were significantly decreased in group 1, almost significantly in group 2 and were significantly increased in group 3 at the end of treatment. A significant improvement of symptoms as well as production of leukocyte migration inhibition against brucella antigens were noted in both groups 1 and 2, in contrast to group 3. This response to treatment was however greater in group 1. These findings demonstrate that immunotherapy resulted in both clinical and immunological improvement and that interferon seems to be a more promising therapeutic approach of chronic brucellosis.
点击下载:
PDF (857KB)
返 回