Existence of capsaicin‐sensitive glutamatergic terminals in rat hypothalamus
作者:
Takashi Sasamura,
Miwa Sasaki,
Chihiro Tohda,
Yasushi Kuraishi,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 9
页码: 2045-2048
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Capsaicin-evoked glutamate release;Cerebellum;Dorsal horn;Hypothalamus;Vanilloid receptor subtype 1 mRNA
数据来源: OVID
摘要:
CAPSAICIN has been suggested to act not only on thin primary afferents but also on the hypothalamus, but the neurotransmitter(s) of central capsaicin-sensitive neurons are unknown. The present study was conducted to determine whether any central, especially hypothalamic, glutamatergic terminals were sensitive to capsaicin. Capsaicin evoked glutamate release from slices of hypothalamus and lumbar dorsal horn, but not cerebellum. Such capsaicin action was Ca2+dependent and inhibited by the capsaicin antagonist capsazepine. Vanilloid receptor subtype 1 mRNA was widely distributed in the brain, with a marked level in the hypothalamus and cerebellum, but not in the spinal cord. The results suggest that there are glutamatergic terminals sensitive to capsaicin in the hypothalamus.
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