HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC ASSAY AND DRUG DISSOLUTION STUDIES OF FLUOXETINE HYDROCHLORIDE IN CAPSULE FORMULATIONS
作者:
Niyazi Yilmaz,
Yalçin Özkan,
SibelA. Özkan,
Inci Biryol,
HassanY. Aboul-Enein,
期刊:
Journal of Liquid Chromatography & Related Technologies
(Taylor Available online 2000)
卷期:
Volume 23,
issue 11
页码: 1699-1710
ISSN:1082-6076
年代: 2000
DOI:10.1081/JLC-100100446
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
A sensitive and simple high performance liquid chromatographic method for the assay of fluoxetine HCl was developed. The procedure is based on the use of the reversed-phase high performance liquid chromatographic method with UV detector. Each analysis required no longer than 6 minutes. The detector response was linear in the range of 0.01–50 μg/mL for fluoxetine HCl. The detection limit was found to be 0.0057 μg/mL. There was no significant difference between interday and intraday studies for fluoxetine HCl determined for two different concentrations. This method was applied, without any interferences from the excipients, for the determination of the drug in capsules and in drug dissolution studies. This method can be useful in routine quality control analysis of fluoxetine HCl pharmaceutical dosage form.
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