POSSIBLE ROLE OF GLUTATHIONE IN PREVENTION OF ACETAMINOPHEN-INDUCED HEPATOTOXICITY ENHANCED BY FISH OIL IN MALE WISTAR RATS
作者:
Filiz Kuralay Ulus S. Akarca A. Omer Ozutemiz Fatma Kutay Yucel Batur,
期刊:
Journal of Toxicology and Environmental Health, Part A
(Taylor Available online 1998)
卷期:
Volume 53,
issue 3
页码: 223-229
ISSN:1528-7394
年代: 1998
DOI:10.1080/009841098159358
出版商: Informa UK Ltd
数据来源: Taylor
摘要:
It has been reported that fish oil protects the rat liver against acetaminophen (APAP) induced toxicity; however, this finding is controversial. The present study was undertaken to investigate the effects of fish oil-enriched diet on APAP-induced liver injury in Wistar rats. Rats were fed a diet supplemented with either 8% fish oil or 8% corn oil, or standard rat feed for 6 wk. After an overnight fast, rats in each group were given either 2 g/kg APAP or saline orally. Our findings showed that APAP increased serum alanine aminotransferase (ALT) and that this rise was potentiated in the presence of dietary fat. Further fish oil ingestion increased the glutathione (GSH) content in rat liver; however, this was not effective in protecting liver from APAP-induced toxicity. Data suggest that GSH may be necessary to detoxify APAP metabolites, which are known to induce hepatotoxicity but are increased by dietary fat.
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