Effect of Passive Transfer of Human Anti-Myelin-Associated Glycoprotein IgM in Marmoset
作者:
DanceaSylvia,
DellagiKoussay,
RenaudFrancis,
MahouyGuy,
JacquesJean,
ClaudeJean,
期刊:
Autoimmunity
(Taylor Available online 1989)
卷期:
Volume 3,
issue 1
页码: 29-37
ISSN:0891-6934
年代: 1989
DOI:10.3109/08916938909043611
出版商: Taylor&Francis
关键词: IgM neuropathy;myelin associated glycoprotein;passive transfer;marmoset;Schmidt-Lanterman incisures.
数据来源: Taylor
摘要:
Adult and one week old marmosets were injected intravenously within a one month period or intraperitoneally within a 6 week period respectively, with monoclonal IgM having an anti-myelin associated glycoprotein antibody activity. No clinical or electrophysiological abnormalities could be detected in experimental animals. However, indirect immunofluorescence studies showed IgM deposition in close contact to myelin sheaths. Minor but distinct alterations of nerves werre found in the adult: the enlargement of Schmidt-Lanterman incisures seen in electron microscopy could explain the decrease of the proportion of fibers of small diameter found by morphometry of semi-thin section, and the reduction of the mean internodal length in fibers of a given diameter seen in teased nerve fibers studies.
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