Use of ACAID to suppress interphotoreceptor retinoid binding protein-induced experimental autoimmune uveitis
作者:
HaraYoshiyuki,
CaspiRachel R.,
WiggertBarbara,
ChaoChi,
StreileinJ. Wayne,
期刊:
Current Eye Research
(Taylor Available online 1992)
卷期:
Volume 11,
issue sup1
页码: 97-100
ISSN:0271-3683
年代: 1992
DOI:10.3109/02713689208999517
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Experimental Autoimmune Uveitis (EAU) was induced by immunization with bovine interphotoreceptor retinoid binding protein (IRBP) in B10.A mice. The experiments were performed to evaluate whether Anterior Chamber Associated Immune Deviation (ACAID) can be induced by IRBP when injected intracamerally. The results indicate that anterior chamber (AC) injection of IRBP impaired the development of IRBP-specific delayed hypersensitivity and prevented the expression of EAU following immunization with IRBP-CFA. Adoptive transfer of spleen cells obtained from mice that received IRBP into AC suppressed EAU, whether administered prior to or after the uveitogenic regimen. Most important, IRBP-specific suppressor cells from AC-IRBP treated mice when injected into IRBP-EAU mice suppressed and eliminated already established intraocular inflammation. IRBP-specific, ACAID-inducing suppressor T cells act on the efferent limb of the immune response, and represent ideal modalities for treating already established EAU.
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