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Simultaneous Determination of Naphazoline Nitrate and Tetramethylthionine Base in Eye Drops by First-Derivative UV Spectrophotometry

 

作者: J. Joseph-Charles,   M. Bertucat,  

 

期刊: Analytical Letters  （Taylor Available online 1999）
卷期: Volume 32, issue 2  

页码: 373-382

 

ISSN:0003-2719

 

年代: 1999

 

DOI:10.1080/00032719908542826

 

出版商: Taylor & Francis Group

 

关键词: Naphazoline nitrate;Tetramethylthionine base;Simultaneous determination;First-derivative spectrophotometry;Eye drops

 

数据来源: Taylor

 

摘要:

A rapid first-derivative spectrophotometric method for the simultaneous determination of naphazoline nitrate and tetramethylthionine base in eye drops by using zero-crossing measurements is described. Solutions of this drug combination in water were analysed by measurement of the amplitudes at 257.2 and 247.5 nm, respectively. Good linearity, accuracy, precision and selectivity were found, and the method is proposed for routine quality control purposes.

 

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