Clearance rate of macrophages from the vitreous in rabbits
作者:
van MeursJan C.,
SorgenteNino,
GaudermanW. Jim,
RyanStephen J.,
期刊:
Current Eye Research
(Taylor Available online 1990)
卷期:
Volume 9,
issue 7
页码: 683-686
ISSN:0271-3683
年代: 1990
DOI:10.3109/02713689008999584
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Macrophages are usually present in epiretinal membranes from eyes with proliferative vitreoretinopathy (PVR). Information on the kinetics of macrophages in the eye may be of help in identifying their role in this disease. To determine the half-life of macrophages in the vitreous, peritoneal macrophages were labeled by allowing them to phagocytose141Cerium (gammaemitter) labeled microspheres, and were then injected into the vitreous of the same rabbit from which they were obtained. The animals were sacrificed at various times post-injection and the radioactivity remaining in the vitreous was measured. Using this procedure, the half-life was found to be 4.8 days.
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