Mutagenicity of Inhaled Anesthetics inDrosophila melanogaster
作者:
Yashdev,
Kundomal Jeffrey,
Baden Lawrence,
期刊:
Anesthesiology
(OVID Available online 1985)
卷期:
Volume 62,
issue 3
页码: 305-309
ISSN:0003-3022
年代: 1985
出版商: OVID
关键词: Anesthetics, gases: nitrous oxide;Anesthetics, volatile: enflurane;fluroxene;halothane;isoflurane;Toxicity: mutagenicity
数据来源: OVID
摘要:
The mutagenic effects of several inhaled anesthetic agents were investigated using the sex-linked recessive lethal assay in the fruit fly,Drosophila melanogaster. Male wild-type flies were exposed for 1 hr to either halothane, enflurane, isoflurane, or fluroxene at vapor concentrations of 1 or 2% or to nitrous oxide at concentrations of 40 or 80%. Control flies were exposed to air alone. Following treatment, male flies were mated with untreated virgin females of theBascstrain and the rate of sex-linked recessive lethals was determined in the F2generation. Halothane and fluroxene produced a dose-dependent and statistically significant increase in the rate of sex-linked recessive lethals, whereas enflurane, isoflurane, and nitrous oxide were not mutagenic at the concentrations tested.
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