Effects of a Long‐chain fatty amine on mammary carcinogenesis induced in female Sprague‐dawley rats by DMBA
作者:
ParenteauHeli,
HoTe‐FuLin,
EckelLisaA.,
CarrollKennethK.,
期刊:
Nutrition and Cancer
(Taylor Available online 1992)
卷期:
Volume 17,
issue 3
页码: 235-241
ISSN:0163-5581
年代: 1992
DOI:10.1080/01635589209514192
出版商: Taylor&Francis Group
数据来源: Taylor
摘要:
AbstractReports that protein kinase C is inhibited by sphingosine and other long‐chain amines and the suggestion that promotion of mammary carcinogenesis by dietary fat is mediated by protein kinase C prompted us to investigate the effects of a long‐chain amine, 1‐octa‐decylamine, on mammary carcinogenesis induced by 7,12‐dimethylbenz[a]anthracene in rats fed a high‐fat diet. Rats fed the amine sulfate at a level of 0.01% in a semipurified diet containing 20% corn oil developed more tumors than those fed the high‐fat diet alone, although body weight gain was inhibited slightly. Rats fed the amine sulfate at 0.1% of the diet developed very few tumors compared with those fed either the high‐fat diet or a low‐fat diet containing 5% corn oil. At the higher level, the C18 amine also caused a marked inhibition of body weight gain.
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