Effects of Dietary Polyamine Precursors on the Metabolism and Tissue Concentrations of Amino Acids in the Rat
作者:
Trevor K. Smith,
Leena Lindqvist,
Liisa Alakuijala,
Terho O. Eloranta,
期刊:
Annals of Nutrition and Metabolism
(Karger Available online 1989)
卷期:
Volume 33,
issue 3
页码: 143-152
ISSN:0250-6807
年代: 1989
DOI:10.1159/000177531
出版商: S. Karger AG
关键词: Methionine;Arginine;Ornithine;Difluoromethylornithine;Liver;Muscle;Amino acids;tRNA acylation
数据来源: Karger
摘要:
Experiments were conducted to determine the effects of dietary supplements of amino acid precursors of polyamines on amino acid metabolism in the rat in order to better understand comparative aspects of polyamine metabolism. Rats were fed isonitrogenous combinations of methionine, ornithine, arginine and 2-difluoromethylornithine in casein-based diets. It was observed that hepatic concentrations of methionine, 5’-deoxy-5’-methylthioadenosine and decarboxylated S-adenosylmethionine were more easily influenced by diet than were arginine and metabolites. It was concluded that rats may be more refractory to exogenous polyamine precursor amino acids than are chicks because of the presence of a functional urea cy
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