Treatment of Psoriasis vulgaris with a New Retinoic Acid Derivative Ro 10-9359
作者:
Birgit Dahl,
Kirsten Møllenbach,
Flemming Reymann,
期刊:
Dermatology
(Karger Available online 1977)
卷期:
Volume 154,
issue 5
页码: 261-267
ISSN:1018-8665
年代: 1977
DOI:10.1159/000251079
出版商: S. Karger AG
关键词: Retinoic acid derivative Ro 10-9359;Psoriatics;Changes in alkaline phosphatase and glutamic-aspartatic transaminase
数据来源: Karger
摘要:
The retinoic acid derivative Ro 10-9359, given orally in maximum daily doses of 100 mg to 15 patients with psoriasis vulgaris, led to clearing of the lesions in 8 patients. The average period of treatment was 9 weeks. In 14 patients side-effects were observed, the most important being palmo-plantar desquamation, shivering, thirst and diffuse hair loss. In 2 patients scaling led to withdrawal. In 6 patients abnormal alkaline phosphatase and glutamic-aspartatic transaminase values, partly transient, developed (glutamic-aspartatic transaminase, p < 0.01).
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