Circulatory responses to afterloading with phenylephrine in hyperdynamic sepsis
作者:
TOJI YAMAZAKI,
YASUHIRO SHIMADA,
NOBUYUKI TAENAKA,
HISATOSHI OHSUMI,
JUN TAKEZAWA,
IKUTO YOSHIYA,
期刊:
Critical Care Medicine
(OVID Available online 1982)
卷期:
Volume 10,
issue 7
页码: 432-435
ISSN:0090-3493
年代: 1982
出版商: OVID
数据来源: OVID
摘要:
We assessed cardiac function by acute pressure loading with phenylephrine in 7 patients who had hyperdynamic sepsis and in 8 patients who had heart disease. All patients with sepsis had a positive Limulus lysate test, a septic focus, and a cardiac output (CO) greater than 6.0 L/min. Phenylephrine was given iv to elevate systolic arterial pressure by 30 mm Hg. Cardiac index (CI) and stroke index (SI) increased significantly in patients with hyperdynamic sepsis, whereas systemic vascular resistance index (SVRI) showed no change. In patients with heart disease, CI and SI decreased significantly, whereas SVRI increased significantly. The marked differences in response to phenylephrine by the two groups suggest lack of cardiac dysfunction in patients with hyperdynamic sepsis.
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