Choline Acetyltransferase Activity in Omental Tissue
作者:
GoldsmithHarry S.,
MarquisJudith K.,
SiekGordon,
期刊:
British Journal of Neurosurgery
(Taylor Available online 1987)
卷期:
Volume 1,
issue 4
页码: 463-466
ISSN:0268-8697
年代: 1987
DOI:10.3109/02688698708999637
出版商: Taylor&Francis
关键词: Alzheimer's disease;Omental transplantation;Choline acetyltransferase;Cerebral revascularization
数据来源: Taylor
摘要:
Choline acetyltransferase (ChAT), the enzyme responsible for the formation of ACh from choline and acetyl-coenzyme A, is a marker of cholinergic function and is significantly depressed in the brains of Alzheimer patients. It has been shown that omental tissue contains several neuroactive substances and causes revascularization when placed upon the brain of stroke patients. In this study, it was demonstrated that omental tissue exhibits specific ChAT activity. This activity was choline-dependent, inhibited by N-ethylmaleimide (a known ChAT inhibitor), and was characterized by kinetic parameters consistent with values for the neuronal enzyme. It is suggested that omental placement to the brain together with oral choline administration might prove to be useful for increasing ACh synthesis in Alzheimer's disease.
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