Interactions of functionalized polystyrene derivatives with the complement system in human serum
作者:
B. Montdargent,
D. Labarre,
M. Jozefowicz,
期刊:
Journal of Biomaterials Science, Polymer Edition
(Taylor Available online 1991)
卷期:
Volume 2,
issue 1
页码: 25-35
ISSN:0920-5063
年代: 1991
DOI:10.1163/156856291X00034
出版商: Taylor & Francis Group
关键词: Functionalized polymer surfaces;complement activation;complement inhibition;blood compatibility;biomaterials;hydroxymethylated polystyrene;sulphonated polystyrene
数据来源: Taylor
摘要:
The interactions between blood and insoluble polysaccharidic surfaces result in activation of the immune system of complement. When substituted with carboxymethyl groups, Sephadex loses its capacity to activate complement, whereas Sephadex sulphate has been described as an activator. In order to elucidate the molecular mechanisms of complement activation and inhibition, a simpler polymer model has been choosen: it consists of an insoluble polystyrene backbone on which either isolated hydroxymethyl or sulphonate groups or both are present. The surfaces bearing the isolated groups consume complement but the mechanisms involved are quite different. In contrast, a surface bearing equal proportions of both types of groups is a non-activator. Such model surfaces can be very useful for designing artificial surfaces able to control in situ complement activation.
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