Chromosome analysis of 20 breast carcinomas: Cytogenetic multiclonality and karyotypic‐pathologic correlations
作者:
Nikos Pandis,
Sverre Heim,
Georgia Bardi,
Ingrid Idvall,
Nils Mandahl,
Felix Mitelman,
期刊:
Genes, Chromosomes and Cancer
(WILEY Available online 1993)
卷期:
Volume 6,
issue 1
页码: 51-57
ISSN:1045-2257
年代: 1993
DOI:10.1002/gcc.2870060110
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractShort‐term cultures from 20 breast carcinomas were analyzed cytogenetically. A normal female chromosome complement was found in 4 cases. Clonal chromosome aberrations were detected in 16 tumors. In 10 tumors, multiple cytogenetic clones were found; in 2 cancers the clones were related, reflecting clonal evolution, but in the remaining 8 tumors the clones were cytogenetically unrelated, indicating clonal heterogeneity in the origin of the tumor parenchyma. Correlation analysis between karyotypic and pathologic parameters indicated that cases with complex karyotypes and/or cytogenetically unrelated clones, when compared with cases with a single simple karyotypic abnormality, were generally of higher histologic malignancy grade, had more mitoses in the histologic sections, and also more often had carcinoma in situ lesions in the same breast. © 1993 Wiley‐Liss,
点击下载:
PDF
(525KB)
返 回