Cystinotic Fibroblasts Are Depleted of Free-Cystine by Acid pH Medium
作者:
DAVID RITCHIE,
ADAM JONAS,
ROBERT OSHIMA,
PATRICIA NEAL,
JERRY SCHNEIDER,
期刊:
Pediatric Research
(OVID Available online 1981)
卷期:
Volume 15,
issue 12
页码: 1492-1494
ISSN:0031-3998
年代: 1981
出版商: OVID
数据来源: OVID
摘要:
SummaryThe free (nonprotein) cystine content of human cystinotic fibroblasts was found to vary with the pH of their culture medium. Intracellular cystine content was highest at alkaline medium pH's and lowest at acidic medium pH's. When maintained in medium of pH 6.3, cystinotic fibroblasts lost 50% of their free-cystuie content in 6 hr and over 95% in 30 hr. Cystine was the only amino acid to show significant variation with changes in the pH of the culture medium.
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