The time course of brain activations during response inhibitionevidence from event‐related potentials in a go/no go task
作者:
Markus Kiefer,
Frank Marzinzik,
Matthias Weisbrod,
Michael Scherg,
Manfred Spitzer,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 4
页码: 765-770
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Attention;Event-related potentials;Dipole source localization;Executive control;Go/no go task;Hemispheric specialization;Motor control;N2;P3;Response inhibition
数据来源: OVID
摘要:
THE cortical organization of executive control was investigated using event-related potentials (ERPs). ERPs were collected while subjects performed a go/no go task that required response inhibition. First, around 26ms after stimulus onset, an effect of response inhibition on ERPs was observed over inferior prefrontal areas. Generators in these regions were confirmed by source analysis. Later, between 300–60 ms after stimulus onset, a left lateralized fronto-central ERP effect was found which differed in topography from a non-specific effect of task difficulty. Source analysis indicated that generators in anterior cingulate and left premotor areas also contributed to this effect. Orchestrated activation of prefrontal areas and the anterior cingulate subserves executive function whereas relatively late activity of the left premotor cortex is involved in motor control.
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