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A novel solid phase approach to Aia‐containing peptides

 

作者: Debby Feytens,   Magali De Vlaeminck,   Dirk Tourwé,  

 

期刊: Journal of Peptide Science  （WILEY Available online 2009）
卷期: Volume 15, issue 1  

页码: 16-22

 

ISSN:1075-2617

 

年代: 2009

 

DOI:10.1002/psc.1081

 

出版商: John Wiley&Sons, Ltd.

 

关键词: solid phase peptide synthesis;Trp analog;reductive amination;melanocortin;growth‐hormone‐releasing peptide;feline immunodeficiency virus;conformational constraints;conformational scan

 

数据来源: WILEY

 

摘要:

AbstractA strategy was developed to directly assemble 4‐amino‐1,2,4,5‐tetrahydro‐indolo[2,3‐c]‐azepin‐3‐ones on solid‐phase‐supported peptide sequences. Fmoc‐ and Boc‐based strategies were investigated. The Fmoc‐strategy approach strongly depends on the peptide sequence being synthesized while the Boc‐based synthesis leads to excellent results for all the selected peptide analogs. The method was applied to prepare Aia‐analogs of several bioactive peptides containing one or more Trp‐residues which were shown to be important for biological recognition. Copyright © 2008 European Peptide

 

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