Discrimination of intranasal cocaine
作者:
K.J. Schuh,
H. Schubiner,
C.E. Johanson,
期刊:
Behavioural Pharmacology
(OVID Available online 2000)
卷期:
Volume 11,
issue 6
页码: 511-515
ISSN:0955-8810
年代: 2000
出版商: OVID
关键词: cocaine;discrimination;intranasal;benzocaine;human
数据来源: OVID
摘要:
In the development of medications for the treatment of cocaine abuse, the drug discrimination paradigm can be used to identify medications that can attenuate the discriminative stimulus effects of cocaine. To ascertain that participants are basing the discrimination on the drug's central effects, this paradigm requires that the drug and placebo administrations do not produce any peripheral effects on which the discrimination can be based. This study examined whether intranasal cocaine (50 mg) can be discriminated from placebo (46 mg lactose + 4 mg cocaine), how quickly this discrimination can be made, and whether pretreatment with intranasal benzocaine can affect this discrimination. Results showed that subjects were generally able to discriminate the drug conditions correctly 15 s after administration, and this was unaffected by benzocaine. These results suggest that subjects base the discrimination on peripheral drug effects (e.g. taste) that are not affected by anaesthesia of the nasal passage, and that the intranasal route of cocaine administration is unlikely to be feasible with a drug discrimination paradigm.
点击下载:
PDF
(5234KB)
返 回