Embryotoxicity of the folate antagonist methotrexate in rats and rabbits
作者:
Robert L. Jordan,
James G. Wilson,
Herbert J. Schumacher,
期刊:
Teratology
(WILEY Available online 1977)
卷期:
Volume 15,
issue 1
页码: 73-79
ISSN:0040-3709
年代: 1977
DOI:10.1002/tera.1420150110
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractThe prenatal effects of methotrexate (MTX) in rats and rabbits were assessed. It was found highly embryotoxic in postimplantation rat embryos; 0.3 mg/kg ip or less caused nearly total embryolethality with slight teratogenicity. Rabbit embryos were far more resistant to small doses of MTX than rats, but 19.2 mg/kg iv, when given during days 10 to 15 of gestation, produced little death and a constant spectrum of malformation in a high percentage of offspring. Cleft palate, skull defects, and severe fore‐and hindlimb dysplasias, occurred with a high degree of regularity and were strongly dose and developmental‐stage speci
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