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HB Cleveland orα2β293(F9)CYS→ARG;121(GH4)GLU→GLN

 

作者: WilsonJ. B.,   RamachandranM.,   WebberB. B.,   KutlarF.,   HazelnoodL. F.,   BarnettD.,   HirschlerN. V.,   HuismanT. H. J.,  

 

期刊: Hemoglobin  （Taylor Available online 1991）
卷期: Volume 15, issue 4  

页码: 269-278

 

ISSN:0363-0269

 

年代: 1991

 

DOI:10.3109/03630269109027879

 

出版商: Taylor&Francis

 

数据来源: Taylor

 

摘要:

Hb Cleveland is characterized by two amino acid Substitutions, namelyβ121(GH4)Glu→Gln as in Hb D-Los Angeles andβ93(F9)Cys→Arg as in Hb Okazaki, and shares with Hb Okazaki a decreased stability, an increase in oxygen affinity, and decreases in Bohr effect and heme-heme interaction. It is the 13thβchain variant with two substitutions that has been described thus far.

 

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