Biliary Excretion of Cefaclor
作者:
Jean-Marie Brogard,
Michel Pinget,
Françoise Comte,
Michel Adloff,
Jean Lavillaureix,
期刊:
Chemotherapy
(Karger Available online 1982)
卷期:
Volume 28,
issue 3
页码: 189-199
ISSN:0009-3157
年代: 1982
DOI:10.1159/000238075
出版商: S. Karger AG
关键词: Cefaclor;Biliary excretion;Rabbit liver perfusion;T-tube drainage;Intraoperative sampling
数据来源: Karger
摘要:
Biliary excretion of cefaclor, a new orally active cephalosporin, was studied in vitro using an isolated rabbit liver preparation perfused for 3 h (n = 5). Under these conditions, bile recovery amounted to 2.3% of the cefaclor dose added to the circulating blood (10 mg). In humans, after oral administration of a 1-gram dose of cefaclor to cholecystec-tomized patients provided with a T tube (n = 10), a mean biliary peak concentration of 7.6 ± 2.4 μg/ml was observed at the 3rd hour. Cumulative biliary excretion amounted to 0.05% of the administered dose. Assays performed on samples collected during chole-cystectomy in 10 patients 1 h after intake of a 1-gram dose of cefaclor showed mean concentrations of 13.7 ± 1.2 μg/ml in serum, 8.1 ± 1.3 μg/ml in common duct bile and 5.9 ± 1.4 μg/ml in gallbladder bile. These results were compared with the data obtained after administration of seven other cephalosporins studied under identical con
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