Effects of halothane and colchicine on microtubules and electrical activity of rabbit vagus nerves
作者:
Robert E. Hinkley,
Louis S. Green,
期刊:
Journal of Neurobiology
(WILEY Available online 1971)
卷期:
Volume 2,
issue 2
页码: 97-105
ISSN:0022-3034
年代: 1971
DOI:10.1002/neu.480020202
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractRabbit vagus nerves were treatedin vitrowith colchicine and halothane, an anesthetic, and the electrical activity monitored. The number of microtubules per square micron of axonal area was measured for each treatment directly from electron micrographs with the aid of a planimeter. Colchicine (10 mM) significantly reduced the number of microtubules per square micron of axonal area from 40 to 16 and had little effect on the electrical activity. Halothane (3 and 10 mM) significantly increased the number of microtubules from 40 to about 55 per square micron of axonal area and blocked the ability of the nerve to propagate impulses within 25 and 10 min, respectively.
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