BONE MARROW TRANSPLATATION IN MINIATURE SWINEI. Development of the Model
作者:
Larry,
Pennington Kaoru,
Sakamoto Frederique,
Popiotz-Bergez Mark,
Pescovitz Margaret,
McDonough Thomas,
MacVittie Ronald,
Gress David,
期刊:
Transplantation
(OVID Available online 1988)
卷期:
Volume 45,
issue 1
页码: 21-26
ISSN:0041-1337
年代: 1988
出版商: OVID
数据来源: OVID
摘要:
Procedures for successful autologous and MHC-matched allogeneic bone marrow transplantation in partially inbred, MHC-defined miniature swine have been established. All marrow recipients were conditioned with single-dose total-body irradiation at the upper level of tolerance, and supported with antibiotics and irradiated blood products during aplasia. Surgical harvest of autologous and allogeneic marrow yielded sufficient numbers of cells to successfully reocnstitute recipients. Radiation control animals that reveived no marrow failed to show recovery of marrow function. Pigs transplanted with autologous marrow at dosed greater than108cells/kg/ routinely engrafted and recovered normal marrow function. The major clinical complications were acute and chronic infections and hemorrhage. T cell-depleted autologous marrow also engrafted, and there was no observed increase in clinical complications. In bone marrow transplantation across non-MHC allogeneic differences, engraftment and survival were similar
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