Effect of cyproterone acetate on the reproductive system of the female rat
作者:
Manjula Arya,
Somnath Gupta,
V.P. Dixit,
期刊:
Cells Tissues Organs
(Karger Available online 1979)
卷期:
Volume 103,
issue 3
页码: 259-265
ISSN:1422-6405
年代: 1979
DOI:10.1159/000145023
出版商: S. Karger AG
关键词: Cyproterone acetate;Reproductive system;Rats;Antifertility;Oestrogenic effect
数据来源: Karger
摘要:
Effects of cyproterone acetate, a synthetic steroidal compound, on the reproductive organs of female rats have been investigated. This agent caused reduction of ovarian weights indicative of suppression of pituitary gonadotrophins. Oestrogenic nature of cyproterone acetate was investigated in intact and ovariectomized rats taking uterine weight and vaginal keratinization as an index of oestrogenicity. Cyproterone acetate in ovariectomized animals induced vaginal keratinization and increased the uterine weights. These effects were parallel to the effect of oestradiol dipropionate in ovariectomized animals, thus indicating oestrogenic activity of cyproterone acetate. We may conclude that the above compound caused antifertility effects due to its oestrogenic nature at the dose level of 2 mg/alternate day in rats when the compound was administered subcutaneously.
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