Three selenium-containing compounds, diphenyl selenide, benzyl phenyl selenide and dibenzyl selenide were used as neutral carriers to make a Ag+-selective membrane electrode. All three compounds exhibited higher sensitivity to Ag+than the corresponding sulfides and ethers. The highest sensitivity was obtained by dibenzyl selenide and an electrode constructed using this carrier and bis(l-butylpentyl) adipate as a membrane solvent in a poly(vinyl chloride) membrane matrix exhibited a near-Nernstian response to Ag+in the concentration range from 1 x 10−5to 1 x 10−2M with a slope of 52 mV per concentration decade. The lower limit of detection was around 1 μM. The ion selectivity of this electrode for Ag+was over 104times that for other metal cations. Dibenzyl selenide and Ag+interactions were examined by1H-NMR spectroscopy.