Intravenous Infusion of Enprofylline with an Exponentially Decreasing Drug Concentration in Acute Asthma
作者:
Krister Arnman,
Bo Willén,
Lars Borgström,
Thor-Björn Conradson,
期刊:
Therapeutic Drug Monitoring
(OVID Available online 1989)
卷期:
Volume 11,
issue 3
页码: 249-252
ISSN:0163-4356
年代: 1989
出版商: OVID
关键词: Acute asthma;Administration by intravenous infusion;Enprofylline;Plasma concentration.
数据来源: OVID
摘要:
Summary: Nine patients (3 women), aged 29–78 years, with acute asthma were treated with the antiasthma xanthine, enprofylline, in an open-design study without a reference drug. Enprofylline was administered intravenously (i.v.) over 2 h with an exponentially decreasing concentration. This alternative infusion system was found to be simple to handle. All patients but one reached a therapeutic plasma concentration of enprofylline within 20 min, but with a lower peak plasma concentration as compared to what previously has been found with a conventional i.v. injection of the same amount of drug. The plasma concentration of enprofylline remained on a stable and therapeutic level over the 2-h observation period. The effect on lung function was comparable to that found in other controlled trials with enprofylline. A system for i.v. administration of drugs with an exponentially decreasing concentration as an alternative to manually given i.v. injections should be further evaluated.
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