Combined Effect of Terbutaline and Betamethasone on Glucose Homeostasis in Preterm Labor
作者:
Karolina Adam,
Ching-Nan Ou,
David B. Cotton,
期刊:
Fetal Diagnosis and Therapy
(Karger Available online 1993)
卷期:
Volume 8,
issue 3
页码: 187-194
ISSN:1015-3837
年代: 1993
DOI:10.1159/000263823
出版商: S. Karger AG
关键词: Terbutaline;Betamethasone;Glucose homeostasis
数据来源: Karger
摘要:
The short- and long-term effects of simultaneous administration of terbutaline and betamethasone were investigated in 8 gravidas treated for preterm labor. Their plasma concentrations of glucose, insulin, glucagon, C-peptide, lactate and potassium were compared to a control group receiving intravenous magnesium sulfate and betamethasone. The patients on terbutaline therapy had a marked hyperglycemia at 11 h which remained elevated for 48 h. There was a simultaneous rise in plasma insulin and C-peptide, and a fall in plasma glucagon. Lactate levels were markedly elevated. Only 1 of the 8 patients had an abnormal glucose tolerance test at 1 week of therapy. The metabolic changes of control patients were minimal in comparison and there was no lacticacidemia. This suggests that glucocorticoids potentiate the hyperglycemic response of terbutaline.
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