Platelet Heterogeneity and Coronary Artery Thrombosis
作者:
KristensenSteen D.,
MartinJohn F.,
期刊:
Platelets
(Taylor Available online 1991)
卷期:
Volume 2,
issue 1
页码: 11-17
ISSN:0953-7104
年代: 1991
DOI:10.3109/09537109109005497
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Platelets are produced from megakaryocytes. Under normal physiological conditions changes in platelet volume and density are not secondary to ageing but are present at thrombopoiesis. Prolonged increased platelet destruction rate leads to the production of large platelets from large, high ploidy megakaryocytes. In vivo and ex vivo studies show such platelets have more haemostatic potential. Platelets are larger and denser in acute myocardial infarction, where bleeding time is shortened and bleeding time aspirin sensitivity is increased. Thromboxane A2formation is increased in unstable angina pectoris and in acute myocardial infarction. Megakaryocytes are enlarged in acute myocardial infarction and in sudden unexpected cardiac death. Megakaryocyte and platelet changes may precede coronary artery thrombosis.
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