In vitro Effects of lonophores and Inhibitors of Main Sodium and Calcium Movements on Tyrosine and Tryptophan Transport by Human Erythrocytes
作者:
J. Widmer,
J.-M. Gaillard,
Y. Raffin,
D. Mouthon,
R. Tissot,
期刊:
Neuropsychobiology
(Karger Available online 1986)
卷期:
Volume 16,
issue 4
页码: 175-180
ISSN:0302-282X
年代: 1986
DOI:10.1159/000118322
出版商: S. Karger AG
关键词: L-Tyrosine;L-Tryptophan;Erythrocytes;Membrane transport
数据来源: Karger
摘要:
Peripheral models using blood cells might be biochemical markers in various psychiatric illnesses. In previous papers we reported a deficit of tyrosine and tryptophan transport in red cells incubated in plasma from depressed patients. In the present study we investigated the role played by sodium and calcium in these transports by using inhibitors and ionophores of the main movements of these electrolytes. We also studied the contribution of phloretin-sensitive countertransport, which has been described as low in psychiatric conditions.
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