The Inhibitory Effect of Diethylaminoethyl Diphenylvalerate (SKF 525‐A) on Glucuronidation by Cultures of Rat Hepatoma Cells
作者:
E. Dybing,
H. E. Rugstad,
期刊:
Acta Pharmacologica et Toxicologica
(WILEY Available online 1973)
卷期:
Volume 32,
issue 1‐2
页码: 112-118
ISSN:0001-6683
年代: 1973
DOI:10.1111/j.1600-0773.1973.tb01455.x
出版商: Blackwell Publishing Ltd
关键词: Drug metabolism;SKF 525‐A;glucuronyl;transferase;cell culture
数据来源: WILEY
摘要:
Abstract:SKF 525‐A at concentrations from 10−5M to 2 × 10−4M inhibits the glucuronidation ofp‐aminophenol (PAP),p‐nitrophenol (PNP), and bilirubin by a clonal strain of rat hepatoma cells (MH1C1) grown in culture. At higher concentrations of SKF 525‐A the glucuronidation of PAP and PNP in a homogenate system from the cell cultures and normal rat liver is also inhibited, PAP to the greatest extent. The inhibition of PAP glucuronidation in the homogenate system appears to be of the non‐co
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