Elevated Cytokine Levels in Synovial Fluid of Rheumatoid Arthritis Correlates with the Presence of Cytomegalovirus Genome
作者:
MurayamaT.,
TsuchiyaN.,
JisakiF.,
OzakiM.,
SakamuroD.,
HiraiK.,
ShimizuS.,
ItoK.,
MatsushimaK.,
FurukawaT.,
期刊:
Autoimmunity
(Taylor Available online 1994)
卷期:
Volume 17,
issue 4
页码: 333-337
ISSN:0891-6934
年代: 1994
DOI:10.3109/08916939409010674
出版商: Taylor&Francis
关键词: CMV;RA;IL-8;IL-6
数据来源: Taylor
摘要:
Synovial fluid aspirated from 34 patients with symptomatic rheumatoid arthritis (RA) was evaluated for the presence of human cytomegalovirus (CMV) genomic material using polymerase chain reaction (PCR), and for levels of interleukin 8 (IL-8) and IL-6 using enzyme-linked immunoadsorbence assay. IL-8 and IL-6 levels were significantly higher in CMV DNA-positive RA patients than CMV DNA-negative RA patients and at least 10-fold higher than in both corresponding control groups of patients with osteoarthritis (OA). These findings suggest an association between elevated IL-8 and IL-6 levels and the presence of the CMV genome in RA patients.
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