Effects of Sulpiride on Persistent Neuroleptic‐induced Dyskinesia in Monkeys
作者:
J‐E Häggström,
期刊:
Acta Psychiatrica Scandinavica
(WILEY Available online 1984)
卷期:
Volume 69,
issue S311
页码: 103-108
ISSN:0001-690X
年代: 1984
DOI:10.1111/j.1600-0447.1984.tb06862.x
出版商: Blackwell Publishing Ltd
关键词: Sulpiride;dyskinesia;monkeys.
数据来源: WILEY
摘要:
AbstractFive Cebus apella monkeys with persistent neuroleptic‐induced dyskinesia were given a single dose of sulpiride (20 mg/kg i.m.). The dyskinesia was reduced in all five although four developed attacks of acute dystonia which had to be reversed by anticholinergic medication in three animals. In one monkey the administration of classic neuroleptics had earlier been shown to induce a typical sequence of events. First there was a similar reduction of dyskinesia as seen in the other monkeys, 1–2 days later there was noticed a rebound deterioration lasting for several days. Metoclopramide 0.5 mg/kg, caused such a rebound effect (for 2 days), whereas sulpiride did
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