Effects of ethanol on methyl mercury toxicity in rats
作者:
Hidehiko Tamashiro,
Mikio Arakaki,
Hirokatsu Akagi,
Kouji Murao,
Kimiko Hirayama,
MichaelH. Smolensky,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1986)
卷期:
Volume 18,
issue 4
页码: 595-605
ISSN:0098-4108
年代: 1986
DOI:10.1080/15287398609530897
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
This study was designed to investigate the effect of different doses of ethanol on the morbidity, mortality, and distribution of mercury in the tissues of groups of rats treated orally once daily with methyl mercury chloride (MMC: 5 mglkg · d) for 10 consecutive days. Ethanol potentiated the toxicity of methyl mercury in terms of neurological manifestations (hindleg crossings and abnormal gait) and mortality. The magnitude of effect depended on the concentration of ethanol administered. The concentration of mercury in the kidney and brain also increased with the dose of ethanol given. These findings indicate that epidemiologic studies designed to evaluate methyl mercury toxicity must take into account the multiple environmental burdens that can affect the population cumulatively and simultaneously.
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