The effects of 0.025% hyoscine hydrobromide eyedrops on visual function in man
作者:
J.D. Morrison,
J. Reilly,
期刊:
Ophthalmic and Physiological Optics
(WILEY Available online 1989)
卷期:
Volume 9,
issue 1
页码: 41-45
ISSN:0275-5408
年代: 1989
DOI:10.1111/j.1475-1313.1989.tb00803.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
Instillation of three drops of 0.025 % hyoscine hydrobromide into one eye at 5 min intervals caused a mydriasis and cycloplegia of rapid onset and of 4–6 days' duration; this was similar to the previously reported actions of concentrations of up to 0.5%. After refraction for the working distance of the experiments, contrast sensitivity to stationary oscilloscope‐generated grating patterns of 10 and 20 c/deg was unaffected despite the mydriasis. Also, contrast sensitivity to laser interference fringes of 10 and 20 c/deg observed in the Maxwellian view, in which the effects of the ocular media are bypassed, was unaffected. Contrast sensitivity to a 3 cydeg phase‐reversed grating pattern was, however, transiently reduced by 40% after hyoscine. A second series of experiments showed a deleterious effect of hyoscine on contrast sensitivity to both stationary and phase‐reversed grating patterns of 2, 3 and 5 c/deg while contrast sensitivity at 10 c/deg was not consistently affected. These results were explained by a direct deleterious action of hyoscine at the level of the retina, specific to channels that detect low spatial freq
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