The prospects of retinoids in the treatment of prostate cancer
作者:
Lisette Hammond,
Geoffrey Brown,
Richard Keedwell,
Jennifer Durham,
Roshantha Chandraratna,
期刊:
Anti-Cancer Drugs
(OVID Available online 2002)
卷期:
Volume 13,
issue 8
页码: 781-790
ISSN:0959-4973
年代: 2002
出版商: OVID
关键词: Apoptosis;differentiation therapy;prostate cancer;retinoids
数据来源: OVID
摘要:
Prostate cancer is the most prevalent cancer amongst males and accounts for 13% of cancer deaths in this population in the US. Aggressive, androgen-independent, metastatic prostate cancer is incurable, and the search for new therapies has been directed towards identifying agents that block proliferation and induce differentiation and/or apoptosis of prostate cancer cells. Retinoid receptor agonists, such as all-transretinoic acid, can induce apoptosis of prostate cancer cells, but clinical studies have demonstrated only mild to moderate efficacy. Retinoic acid receptor antagonists are a new class of retinoids, and pre-clinical studies have shown that they potently inhibit the growth of prostate cancer cells and induce apoptosis. Here, we review whether retinoids have a role in the fight against prostate cancer.
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