Effects of Chlorpromazine and Naloxone on Growth Hormone Secretion in Rats
作者:
Ichiji Wakabayashi,
Megumi Kanda,
Nobuyasu Miki,
Hitoshi Miyoshi,
Eiji Ohmura,
Reiko Demura,
Kazuo Shizume,
期刊:
Neuroendocrinology
(Karger Available online 1980)
卷期:
Volume 30,
issue 5
页码: 319-322
ISSN:0028-3835
年代: 1980
DOI:10.1159/000123021
出版商: S. Karger AG
关键词: Growth hormone secretion;Brain monoamines;Chlorpromazine;β-Endorphin;Naloxone;Somatostatin;GH-RK
数据来源: Karger
摘要:
The present study was conducted to examine roles of brain monoamines and opioid peptides in growth hormone (GH) secretion in unanesthetized, freely behaving rats. The administration of chlorpromazine (CPZ, 300 μg/100 g, i.v.), an antagonist of brain monoamines, to rats that were passively immunized with antiserum to somatostatin immediately lowered plasma GH levels and inhibited episodic GH secretion. An intraventricular injection of β-endorph¡n (3.5 μg) stimulated GH secretion. This effect was completely inhibited by the prior administration of naloxone (100 μg/100 g, i.v.), a specific antagonist of opioid peptides but not by CPZ. In addition, the administration of naloxone did not inhibit episodic GH secretion. The results suggest that CPZ inhibits episodic GH secretion via a factor(s) other than somatostatin. It is also inferred that brain monoamines. but not opioid peptides, play major roles in the regulation of episodic GH secretion in
点击下载:
PDF
(630KB)
返 回