A high performance liquid chromatographic procedure is presented for the determination of ergotamine tartarate and cyclizine hydrochloride in pharmaceutical tablets. An aliquot of the sample is dissolved in methanol containing ethyl p-hydroxybenzoate as an internal standard and chromatographed on a 5 üm, C18, Hibar pre-packed, Lichrospher (250 mm × 4.0 mm i.d.), column using a mobile phase of 0.01 M ammonium acetate in acetonitrile: water: triethylamine (35:64:1) solution, the pH was adjusted to 3.7 with glacial acetic acid. The method was tested for linearity, recovery, and specificity and was found to be fast, sensitive, accurate and reproducible with a total elution time of six min.