Chemoprevention by melatonin and combined melatonin‐tamoxifen therapy of second generation nitroso‐methylurea-induced mammary tumours in rats
作者:
A Kothari,
A Borges,
L Kothari,
期刊:
European Journal of Cancer Prevention
(OVID Available online 1995)
卷期:
Volume 4,
issue 6
页码: 497-500
ISSN:0959-8278
年代: 1995
出版商: OVID
关键词: Melatonin;N-nitroso-N-methylurea;second generation rat mammary tumours;tamoxifen
数据来源: OVID
摘要:
Melatonin, an indole of pineal origin, is known to have an oncostatic effect on carcinogen-induced rat mammary tumours. We have assessed for the first time, the efficacy of melatonin alone and in combination with a sub-optimal dose of tamoxifen, a partial oestrogen antagonist, on N-nitroso-N-methylurea-induced rat mammary tumours. Both these agents were administered to Sprague-Dawley rats following excision of the primary tumours. Melatonin (200 μg/day/rat) at the given dose level could significantly suppress the appearance of second generation mammary tumours and the latency period of tumour appearance was also significantly increased (P< 0.001) as compared to vehicle-treated animals. Tamoxifen (60 μ/week/rat) does not suppress the development of second generation mammary tumours. Co-administration of melatonin and low dose of tamoxifen had no additive or synergistic effect on the prevention of second generation of mammary tumours. The results warrant the clinical evaluation of melatonin for chemoprevention and adjuvant therapy.
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