首页   按字顺浏览 期刊浏览 卷期浏览 Evaluation of31P NMR spectroscopy as an indicator of chemically induced hepatic toxicit...
Evaluation of31P NMR spectroscopy as an indicator of chemically induced hepatic toxicity in the rat: Comparison with serum enzyme levels and pathology

 

作者: G. S. Sandhu,   N. C. Gonnella,   J. C. Kapeghian,   A. F. Plocinski,   J. Plutchok,   M. J. Schlosser,  

 

期刊: NMR in Biomedicine  （WILEY Available online 1991）
卷期: Volume 4, issue 1  

页码: 12-15

 

ISSN:0952-3480

 

年代: 1991

 

DOI:10.1002/nbm.1940040103

 

出版商: John Wiley&Sons, Ltd.

 

数据来源: WILEY

 

摘要:

AbstractThe progression of carbon tetrachloride‐induced liver damage, determined by31P NMR spectroscopy, was compared with selected serum enzyme and histological changes in rats. ATP levels declined as early as 8 h post‐CCI4administration, with partial recovery observed at 168 h. The results show that ATP reduction correlates with necrosis. In addition, early decline in ATP occurring prior to significant hepatocellular necrosis indicates abnormal energy metabol

 

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