Placental and Fetal RNA Metabolism
作者:
T.T. Hayashi,
Dolores Kazmierowski,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1970)
卷期:
Volume 1,
issue 1
页码: 31-38
ISSN:0378-7346
年代: 1970
DOI:10.1159/000301904
出版商: S. Karger AG
关键词: Placental RNA;Fetal RNA;RNA metabolism;Pregnancy;Amino acids;Glucose
数据来源: Karger
摘要:
The incorporation of 14C-labeled L-aspartic acid, L-glutamine, glycine, L-glutamic acid and D-glucose into the fetal and placental RNAs was studied using 14-day pregnant rats. Although all five compounds demonstrated some degree of incorporation, D-14C-glucose was the most effective precursor for both the fetal and placental RNAs. Transfer studies of D-glucose demonstrated a facile transplacental passage, and radiochromatogram analyses showed that D-14C-glucose was incorporated into both the ribose moiety and the nucleic acid bases. In contrast to our previous studies with the near term pregnant rats, there was a normal 18 S radioactivity peak in the placenta RNA resulting from changes in the technique used to extract the placental RNA.
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