Spectroscopic studies on the reaction of iodine as π-acceptor and chloronil as π-acceptor with oxime intermediates prepared from certain pharmaceutical carbonyl compounds are reported. These compounds include Δ1,4-3-corticosteroids (prednisone, prednisolone, dexamethasone), Δ4-3-ketosteroids (progesterone, testosterone propinate, nandrolone phenpropionate), griseofulvin, carvone, and menthone. The spectroscopic techniques applied are IR, far IR spectroscopy, H1, C13NMR, mass spectra (MS), fast atom bombardment mass spectra (FABMS), electron spin resonance (ESR) and microanalysis of the reaction products. The structure elucidation studies of these complexes confirmed the charge transfer complex (CTC) formation.