Application de la Polarographie Sinusoidale au Dosage Sanguin de L'indomethacine
作者:
M. Alkayer,
J.J. Vallon,
Y. Pégon,
C. Bichon,
期刊:
Analytical Letters
(Taylor Available online 1981)
卷期:
Volume 14,
issue 13
页码: 1047-1070
ISSN:0003-2719
年代: 1981
DOI:10.1080/00032718108081447
出版商: Taylor & Francis Group
关键词: Indométhacine;Polarographie Sinusoǐdale;Sérum;Indol-nitrosamine
数据来源: Taylor
摘要:
Alternative current polarography has been applied to indomethacin determination in serum, after dichloromethan extraction at pH 3.0. Solvent is evaporated and the residue submited to hydrolysis by NaOH. The indole derivative obtained is nitrosated by nitrous acid at pH 3,5. The indole-nitrosamine formed is measured by polarography at pH 1,3 and compared with an added quantity of the pure nitrosated product. The proposed method is selective and sensitive; it allows measurement of concentrations in serum as low as o,30 μg ml−1(0.83. 10−9moles ml−1).
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