首页   按字顺浏览 期刊浏览 卷期浏览 CHARACTERISTIC LOCALIZATION OF α1‐ and α2‐ADRENOCEPTORS IN THE HUMAN KIDNEY
CHARACTERISTIC LOCALIZATION OF α1‐ and α2‐ADRENOCEPTORS IN THE HUMAN KIDNEY

 

作者: Kohsuke Minamisawa,   Satoshi Umemura,   Nobuhito Hirawa,   Shuichi Hayashi,   Yoshiyuki Toya,   Yoshihiro Ishikawa,   Gen Yasuda,   Masao Ishii,  

 

期刊: Clinical and Experimental Pharmacology and Physiology  （WILEY Available online 1993）
卷期: Volume 20, issue 7‐8  

页码: 523-526

 

ISSN:0305-1870

 

年代: 1993

 

DOI:10.1111/j.1440-1681.1993.tb01735.x

 

出版商: Blackwell Publishing Ltd

 

关键词: α1‐adrenergic receptor;α2‐adrenergic receptor;cortex;kidney;medulla.

 

数据来源: WILEY

 

摘要:

SUMMARY1. The localization of α‐adrenoceptors in the plasma membranes of human kidney were investigated by radioligand binding, using an α1‐antagonist, [3H]‐bunazosin, and an α2‐antagonist, [3H]‐rauwolscine.2. Both the maximum binding (Bmax) and dissociation constant (Kd) of [3H]‐bunazosin were greater in the cortex than in the medulla. TheBmaxof [3H]‐rauwolscine in the medulla was greater than in the cortex.3. Thus, α1‐adrenoceptors appeared to be localized predominantly in the cortex, while the α2‐adrenoceptors were mainly present in the medul

 

点击下载:  PDF (328KB)



返 回