Fate of oligodendrocytes in HIV‐1 infection
作者:
Margaret Esiri,
Christine Morris,
Peter Millard,
期刊:
AIDS
(OVID Available online 1991)
卷期:
Volume 5,
issue 9
页码: 1081-1088
ISSN:0269-9370
年代: 1991
出版商: OVID
关键词: carbonic anhydrase II;CNPase;HIV-1;AIDS;microglia;astrocytes;immunocytochemistry;demyelinating disease;RCA-1 lectin
数据来源: OVID
摘要:
The brains of 22 HIV-1-infected cases and 11 controls, matched for age and sex, were studied with immunocytochemical reactions specific for oligodendrocytes, astrocytes, microglia and HIV-1. In HIV-1 infection, mild degrees of myelin damage were associated with an increase in oligodendrocyte numbers, a change that was reversed in the presence of severe damage. Severity of myelin damage correlated with the extent of astrocytic and microglial reactions expressed in a semi-quantitative manner. HIV-1 p24 antigen was detected in all cases with severe myelin damage and a smaller proportion of cases with lesser degrees of myelin damage. It is concluded that, in HIV-1 infection, oligodendrocytes undergo an initial reactive hyperplasia which may represent an attempt to repair myelin damage.
点击下载:
PDF
(699KB)
返 回